It is possible to drive to Salisbury from north, east, west, and south.

From the west:
U.S. Route 50 passes west-east through Salisbury. It is the major route between Washington, D.C., and Ocean City, Maryland. As BUSINESS Route 50 (designated BUS 50) passes through the center of Salisbury, eastbound travelers will want to turn south on U.S. Business Route 13 toward Salisbury University. We are about two hours east of the Chesapeake Bay bridge at Annapolis, Maryland.

From the north:
U.S. Business Route 13 passes north-south through Salisbury. In fact, it touches the eastern edge of the Salisbury University campus. We are less than three hours south of the Philadelphia, Pennsylvania, area.

From the south:
U.S. Business Route 13 passes north-south through Salisbury. In fact, it touches the eastern edge of the Salisbury University campus. We are less than three hours north of the Norfolk, Virginia, area.

From the east:
Park your submarine at the Ocean City public landing, then take U.S. Route 50 west to Salisbury. In Salisbury, follow the signs to campus.