Yohimbe is a West African tree native to Congo, Cameroon, and
Gabon. The main ingredient is Yohimbine,
is an alkaloid found
in the roots. .
Roots and bark
erectile dysfunction (conflicting studies)
is the alkaloid that is chemically active and responsible for the
effects of yohimbe. It is an
alpha-2 adrenergic receptor.
releases norepinephrine, to increase penile blood flow
15-20 mg. per day
In clinical trials, it
did not effect the sexual performance of sexually functioning men.
It does have a high-risk–to benefit ratio because of side effects:
nervousness, irritability, dizziness, headache, sweating, hypertension,
tachycardia, psychoses, hallucinations, and one report of renal failure,
and a lupus-like
Interactions with other Drugs: OTC stimulants (caffeine,
phenylephedrine, phenylpropanolamine), SSRI's, Tricyclic antidepressants,
and foods containing tyramine.
Renal disease, hepatic disease, psychiatric
and uncontrolled hypertension.
can counteract the benefits of antihypertensive meds.
for CNS and cardiac effects.
Do not use with
Clonidine. It competes with the receptors and can cause a
Yohimbe can counteract mood-modifying meds such as
Warn patients not to use
Due to a weak MAOI activity, do
not eat tyramine
containing foods, or decongestants or
Yohimbine is used widely despite that it does not have FDA approval. It has been
on their unsafe list since 1977
Standard dose is 5.4 mg only by
Yohimbe is a dietary supplement, often in
combination with other herbs.
Recommended to be used under
the care of a physician.